产品货号：
Z12518
中文名称：
CCR10抗体
英文名称：
Anti-CCR10 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-CCR10 Antibody |
| 指标别名 | C C chemokine receptor type 10;C C CKR 10;CC CKR 10;CCR 10;CCR10;G protein coupled receptor 2;GPR2 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB |
| 基因名称 | CCR10 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human GPR2/CCR10(312-327aa FLGLRFRQDLRRLLRG),different from the related rat and mouse sequences by one amino acid. |
| 实际分子量 | 38KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | CCR10,C-C chemokine receptor type 10 is a protein that in humans is encoded by the CCR10 gene.CCR10 is constitutively expressed in skin melanocytes,fibroblasts,and microvascular endothelial cells,and that it is upregulated by IL1B and TNF.Expression was also detected in T cells,Langerhans cells,and peripheral blood mononuclear cells but not in dendritic cells.By fluorescence in situ hybridization,the GPR2 gene is mapped to 17q21.1-q21.3.CCR10 is the receptor for CCL27.CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation.expression of CCL27 in normal keratinocytes and its strong upregulation in skin lesions of atopic dermatitis,contact dermatitis,and psoriasis patients.CCR10+ T lymphocytes were detected in lesional but not normal skin of these patients.Flow cytometric analysis showed that CCL27 binds extracellular matrix components and dermal microvascular endothelial cells and fibroblasts and mediates adhesion and transendothelial migration of CCR10+ circulating leukocytes.CCR10 is predominantly expressed on CD4+CLA+(cutaneous lymphocyte antigen),rather than CD8+,circulating T cells.RT-PCR,confocal microscopy,and ELISA analysis indicated that keratinocytes exposed to TNF or IL1B but not to IL4 or IFNG in vitro express increased CCL27. |
| Uniprot ID | P46092 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | chemokine(C-C motif) receptor 10 |
| 蛋白名全称 | C-C chemokine receptor type 10(C-C CKR-10/CC-CKR-10/CCR-10) |
| 推荐稀释比 | Western blot(WB) 1:500～2000 |
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